Description

Ingenol Mebutate CAS NO 75567-37-2 is a potent diterpenoid ester derived from the plant *Euphorbia peplus*, recognized for its significant biological activity. This compound is a critical active pharmaceutical ingredient (API) valued for its targeted mechanism of action in dermatological treatments. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in developing and producing topical therapies for specific skin conditions.

Application

• Pharmaceutical API: Core active ingredient in prescription topical medications for actinic keratosis.
• Dermatological R&D: Key compound in research for novel topical formulations targeting pre-cancerous skin lesions.
• Preclinical Studies: Used in pharmacological investigations of protein kinase C modulation and its effects on cellular proliferation.
• Compound Library: A high-value reference standard in pharmaceutical and biotechnology screening libraries.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and assay development in pharmaceutical labs.

Basic Information

Product Name	Ingenol Mebutate
CAS No.	75567-37-2
Molecular Formula	C25H34O6
Molecular Weight	430.53 g/mol
Synonyms	Ingenol 3-angelate; PEP005; Ingenol-3-angelate; 3-(2-Methylbut-2-enoyl)ingenol; 20-Deoxyingenol 3-angelate; LEO 432; (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl (2Z)-2-methylbut-2-enoate
EINECS	Contact for details

Quality Control

Our Ingenol Mebutate is manufactured under strict quality systems to meet the exacting standards of pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with ICH guidelines. We are committed to providing material suitable for GMP manufacturing and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). For long-term stability, storage at -20°C under an inert atmosphere is recommended. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.