Description

Dodecanedioic Acid, 1,12-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is a high-purity, reactive diester derivative of dodecanedioic acid, featuring two N-hydroxysuccinimide (NHS) ester groups. This compound is a critical cross-linking and conjugation reagent, enabling the formation of stable amide bonds under mild aqueous conditions. It is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and advanced materials sectors who require reliable, high-performance chemical linkers for modifying biomolecules, creating hydrogels, and synthesizing functional polymers.

Application

• Bioconjugation and Protein Modification: Used to cross-link proteins, peptides, and antibodies with other biomolecules, surfaces, or polymers for diagnostics and therapeutics.
• Polymer Synthesis and Functionalization: Serves as a key monomer or cross-linker in the production of polyamides, polyesters, and other specialty polymers with tailored properties.
• Hydrogel Fabrication: Enables the creation of covalently cross-linked hydrogel networks for drug delivery systems, tissue engineering scaffolds, and wound dressings.
• Surface Immobilization: Facilitates the covalent attachment of bioactive molecules (e.g., enzymes, ligands) to solid supports for biosensors and affinity chromatography media.
• Peptide Synthesis: Acts as an efficient coupling agent in solid-phase peptide synthesis (SPPS) for forming peptide bonds.
• Material Science Research: Employed in R&D for developing novel biomaterials, nanocomposites, and smart materials with specific mechanical or chemical response features.

Basic Information

Product Name	Dodecanedioic Acid, 1,12-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	75472-90-1
Molecular Formula	C20H28N2O8
Molecular Weight	424.45 g/mol
Synonyms	1,12-Bis(2,5-dioxopyrrolidin-1-yl) dodecanedioate; Dodecanedioic Acid Bis(N-hydroxysuccinimide) Ester; Dodecanedioic Acid Bis(NHS) Ester; DDS-NHS; NHS-Dodecanedioate; Bis(N-succinimidyl) dodecanedioate; Dodecanedioic Acid Di(N-succinimidyl) Ester; C12-NHS Ester
EINECS	Contact for details

Quality Control

Our Dodecanedioic Acid, 1,12-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.