Description

Bis-Netropsin is a synthetic, sequence-specific minor groove-binding ligand for double-stranded DNA, derived from the natural antibiotic Netropsin. This compound is valued for its enhanced binding affinity and specificity, making it a powerful tool for molecular biology research and drug discovery. It is primarily utilized by researchers in pharmaceutical development, academic biochemistry, and biotechnology for studying DNA-protein interactions, gene regulation, and as a potential therapeutic agent scaffold.

Application

• Molecular Biology Research: As a high-affinity probe for studying the structure and function of DNA, particularly AT-rich sequences in the minor groove.
• Pharmaceutical Development: Investigation as a lead compound or model for designing novel antiviral and anticancer agents that target genetic material.
• Biochemical Assays: Used in in vitro studies to inhibit specific transcription factors or enzymes that interact with DNA.
• Gene Regulation Studies: Tool for modulating gene expression by blocking the binding site of regulatory proteins on DNA.
• Diagnostic Tool Development: Potential use in the design of sequence-specific DNA detection systems and biosensors.

Basic Information

Product Name	Bis-Netropsin
CAS No.	75472-88-7
Molecular Formula	C₃₈H₅₂N₁₄O₆
Molecular Weight	792.92 g/mol
Synonyms	Bis-netropsin; 1,1'-[1,4-Phenylenebis(methylene)]bis[4-[[(2S)-1-(4-amidinophenyl)-5-[[(2S)-1-(4-amidinophenyl)-5-methyl-1H-pyrrol-2-yl]carbonyl]-4,5-dihydro-1H-pyrrol-2-yl]carbonyl]piperazine]; Phenylenebis(methylene)bis-netropsin; Bis-netropsin derivative; DNA minor groove binder bis-linked; Lexitropsin dimer
EINECS	Contact for details

Quality Control

Our Bis-Netropsin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee product integrity for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.