Description

3,5-Bis(Trifluoromethyl)Toluene is a high-value fluorinated aromatic building block characterized by its electron-deficient aromatic ring and the presence of two powerful trifluoromethyl groups. This compound matters for its unique role in facilitating challenging chemical transformations and imparting desirable properties like enhanced lipophilicity and metabolic stability to target molecules. It is primarily needed by pharmaceutical and agrochemical research & development teams for the synthesis of advanced intermediates, active ingredients, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the preparation of active pharmaceutical ingredients (APIs), particularly for molecules requiring electron-withdrawing substituents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials to modify thermal and optical properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex molecular architectures.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Toluene
CAS No.	75462-61-2
Molecular Formula	C9H6F6
Molecular Weight	228.14 g/mol
Synonyms	α,α,α,α',α',α'-Hexafluoro-3,5-xylenol; 3,5-Bis(trifluoromethyl)methylbenzene; 1-Methyl-3,5-bis(trifluoromethyl)benzene; 3,5-Di(trifluoromethyl)toluene; m-Xylene-α,α,α,α',α',α'-hexafluoride; 3,5-Bis(trifluoromethyl)phenylmethane; Toluene, 3,5-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Toluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting full specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials. Recommended storage temperature is 2-25°C. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.