Description

(3A,5B)-23-Carboxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid CAS NO 75239-91-7 is a high-purity steroidal glucuronide conjugate, a critical intermediate in advanced pharmaceutical research and development. This compound matters for its role in the study of bile acid metabolism and as a reference standard for analytical method development and validation. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of diagnostic reagents focused on metabolic pathways and biomarker discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of bile acid metabolites in biological samples via LC-MS or HPLC.
• Metabolic Pathway Research: Serves as a key intermediate or probe in studying the enterohepatic circulation, detoxification, and transport of steroidal compounds.
• Diagnostic Reagent Manufacturing: Employed in the development of enzyme-linked immunosorbent assays (ELISA) and other diagnostic kits for liver function and metabolic disorders.
• Biomarker Discovery & Validation: Acts as a crucial standard in metabolomics studies aimed at discovering novel biomarkers for hepatobiliary diseases.
• Drug Metabolism and Pharmacokinetics (DMPK): Utilized in in vitro and in vivo studies to understand the glucuronidation process and the pharmacokinetic profile of related drug candidates.
• Academic Research: A vital tool for universities and research institutes investigating steroid biochemistry and conjugation reactions.

Basic Information

Product Name	(3A,5B)-23-Carboxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid
CAS No.	75239-91-7
Molecular Formula	C31H48O9
Molecular Weight	564.72 g/mol
Synonyms	23-Carboxy-24-norcholan-3-yl β-D-glucopyranosiduronic acid; Norcholanic acid glucuronide; 3α,5β-Tetrahydroglucuronide of 23-carboxy-24-norcholanic acid; Tauro-β-muricholate glucuronide (related metabolite); Steroid D-ring glucuronide; Bile acid glucuronide conjugate; 3α-Hydroxy-5β-cholan-24-oic acid 3-glucuronide (structural analog); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our (3A,5B)-23-Carboxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid is produced and controlled under a strict quality management system. We employ advanced analytical techniques including HPLC, LC-MS, and NMR to ensure identity, purity, and consistency, meeting the stringent requirements for research and reference standard applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a low-humidity environment or under inert atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.