Description

(-)-Cotinine CAS NO 75202-09-4 is the major metabolite of nicotine, known for its high purity and stability. This compound is a critical reference standard and intermediate in pharmaceutical and life science research. It is essential for researchers and manufacturers in the fields of analytical chemistry, pharmacology, and diagnostic development who require a reliable and well-characterized biomarker for nicotine exposure and metabolism studies.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quantification of nicotine metabolites in bioanalytical methods, including LC-MS/MS and HPLC.
• Clinical Research & Diagnostics: Serves as a key biomarker in studies investigating smoking behavior, nicotine replacement therapy efficacy, and metabolic pathways.
• Biochemical Research: Employed in enzymatic and receptor-binding assays to study the pharmacological effects and clearance of nicotine.
• Diagnostic Kit Manufacturing: A vital component in the production of immunoassays and point-of-care tests designed to measure cotinine levels in biological samples like urine, saliva, or blood.
• Toxicology Studies: Utilized in forensic and occupational health settings to assess tobacco smoke exposure and passive smoking.
• Chemical Synthesis: Acts as a sophisticated intermediate or starting material for the synthesis of more complex molecules for research purposes.

Basic Information

Product Name	(-)-Cotinine
CAS No.	75202-09-4
Molecular Formula	C10H12N2O
Molecular Weight	176.22 g/mol
Synonyms	(-)-Cotinine; (S)-(-)-Cotinine; (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; Cotinine; S-(-)-Cotinine; Nicotine metabolite; Cotinin; Continine; NSC 407347; (S)-Cotinine
EINECS	Contact for details

Quality Control

Our (-)-Cotinine is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	-84° to -90° (c=1 in ethanol)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.