Description

3-(2-Methylphenyl)-1,1,1-Trifluoro-2-Propanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoromethyl ketone group adjacent to an aromatic ring, making it a versatile precursor for pharmaceuticals and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group contributes to efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers and organic electronic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3-(2-Methylphenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	75199-81-4
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	1,1,1-Trifluoro-3-(o-tolyl)propan-2-one; 2-Methylphenyl Trifluoroacetone; o-Tolyl Trifluoroacetone; 3-(2-Methylphenyl)-1,1,1-trifluoropropan-2-one; 2-Propanone, 1,1,1-trifluoro-3-(2-methylphenyl)-; α,α,α-Trifluoro-2'-methylacetophenone; 1-(2-Methylphenyl)-3,3,3-trifluoropropan-1-one (tautomeric form)
EINECS	Contact for details

Quality Control

Our 3-(2-Methylphenyl)-1,1,1-Trifluoro-2-Propanone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.