Description

Manoalide is a potent and selective phospholipase A2 (PLA2) inhibitor and calcium channel blocker, originally isolated from the marine sponge *Luffariella variabilis*. This compound matters significantly as a critical biochemical tool for studying inflammatory pathways and signal transduction mechanisms in cellular research. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, target validation, and as a reference standard.

Application

• Biochemical Research: Used as a selective inhibitor of phospholipase A2 (PLA2) to study eicosanoid biosynthesis and inflammatory responses.
• Pharmacological Studies: Serves as a key tool compound for investigating calcium signaling pathways and ion channel function.
• Drug Discovery & Development: Acts as a reference standard and lead compound in anti-inflammatory and analgesic drug development programs.
• Cell Biology: Employed in cellular assays to probe the role of PLA2 in membrane dynamics, cell proliferation, and apoptosis.
• Neuroscience Research: Utilized to study neuroinflammation and the modulation of neurotransmitter release.
• Academic Research: A standard reagent in university and institutional labs for teaching and advanced research in enzymology and medicinal chemistry.

Basic Information

Product Name	Manoalide
CAS No.	75088-80-1
Molecular Formula	C25H36O5
Molecular Weight	416.55 g/mol
Synonyms	Manoalide; (3S,4aR,5R,6R,8aS)-5-[(1E)-3-Hydroxy-1-buten-1-yl]-3,6,9,9-tetramethyl-2-oxo-4a,5,6,7,8,8a-hexahydro-3H-naphtho[2,3-b]furan-4-yl (2E,4E)-2,4-octadienoate; Luffariellolide; NSC 326231; L-644,257; CCRIS 5982
EINECS	Contact for details

Quality Control

Our Manoalide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.