Description

Riddelline n-Oxide is a pyrrolizidine alkaloid derivative, specifically the N-oxide form of riddelline. This compound is of significant interest in toxicological research and analytical chemistry as a key metabolite and reference standard. It is primarily utilized by research institutions, pharmaceutical development labs, and contract research organizations (CROs) engaged in safety assessment, metabolic pathway studies, and the development of analytical methods for the detection of pyrrolizidine alkaloids in food, feed, and herbal products.

Application

• Analytical Reference Standard: Serves as a certified high-purity standard for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of pyrrolizidine alkaloids and their metabolites in complex matrices.
• Toxicology and Metabolism Studies: Used in in vitro and in vivo research to investigate the metabolic activation, detoxification pathways, and hepatotoxic mechanisms of riddelline.
• Biomarker Research: Employed in the development and validation of assays to detect specific DNA adducts or protein adducts formed by reactive metabolites of pyrrolizidine alkaloids.
• Pharmaceutical Impurity Profiling: Acts as a known impurity or degradation product reference in the quality control of botanical drug substances and herbal medicinal products.
• Food and Feed Safety: Critical for method development to monitor and control the levels of toxic pyrrolizidine alkaloid contaminants in honey, teas, spices, and animal feed.
• Regulatory Compliance Testing: Supports laboratories in meeting testing requirements set by agencies like the FDA, EFSA, and other global regulatory bodies concerning pyrrolizidine alkaloid limits.

Basic Information

Product Name	Riddelline n-Oxide
CAS No.	75056-11-0
Molecular Formula	C₁₈H₂₃NO₇
Molecular Weight	365.38 g/mol
Synonyms	Riddelline N-Oxide; Riddelliine N-Oxide; 12,18-Didehydro-13,19-dideoxy-7,20-dihydroxysenecionan-11,16-dione 1-oxide; (13Z)-Senecionan-11,16-dione, 12,18-didehydro-13,19-dideoxy-7,20-dihydroxy-, 1-oxide; Riddelline 1-oxide; Riddelliine 1-oxide; PA N-Oxide Reference Standard
EINECS	Contact for details

Quality Control

Our Riddelline n-Oxide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assessment (HPLC), identity confirmation (IR, MS), and residual solvent analysis to ensure it meets the stringent requirements for research and analytical applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.