Description

13,14-Dehydroprostaglandin I2 is a synthetic analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is of significant value in biochemical and pharmacological research for studying cardiovascular physiology, vascular tone regulation, and platelet function. It is primarily utilized by researchers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel therapeutics for hypertension, thrombosis, and pulmonary arterial hypertension.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating prostacyclin receptor (IP receptor) signaling pathways.
• Cardiovascular Studies: Applied in vitro and in vivo models to explore vasodilation, blood pressure regulation, and anti-thrombotic mechanisms.
• Platelet Aggregation Assays: Serves as a key inhibitor in experiments measuring platelet activation and aggregation to understand hemostasis and thrombosis.
• Biochemical Tool Compound: Employed to elucidate the structure-activity relationships (SAR) of prostacyclin analogs for drug discovery programs.
• Cell Signaling Research: Utilized to study cyclic AMP (cAMP)-mediated cellular responses in vascular smooth muscle and endothelial cells.
• Reference Standard: Provides a high-purity benchmark for analytical methods such as HPLC and LC-MS in quality control and metabolic studies.

Basic Information

Product Name	13,14-Dehydroprostaglandin I2
CAS No.	74853-73-9
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	13,14-didehydroprostacyclin; 13,14-Didehydro-PGI2; 15-Dehydroprostacyclin; 13,14-Dehydro-PGI2; U-51605; 5,6,13,14-Tetradehydroprostacyclin; (5Z,13E,15S)-6,9α-Epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oic Acid
EINECS	Contact for details

Quality Control

Our 13,14-Dehydroprostaglandin I2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic and should be kept in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.