Description

16(S)-Iloprost is a synthetic analogue of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This high-purity compound is critical for advanced pharmaceutical research and development, particularly in the study of pulmonary arterial hypertension (PAH) and other vascular disorders. It is an essential reference standard and active pharmaceutical ingredient (API) intermediate for manufacturers and research institutions focused on cardiovascular therapeutics.

Application

• Pharmaceutical Reference Standard: Used for quality control, method validation, and calibration in analytical laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic building block in the production of iloprost-based medications.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate mechanisms of vasodilation, platelet function, and vascular remodeling.
• Pulmonary Arterial Hypertension (PAH) Research: A vital tool for preclinical studies targeting the prostacyclin pathway for new PAH treatment development.
• Cell Culture & Signaling Studies: Used to study the effects of prostacyclin analogues on endothelial cells, smooth muscle cells, and other relevant cell types.

Basic Information

Product Name	16(S)-Iloprost
CAS No.	74843-14-4
Molecular Formula	C₂₂H₃₂O₄
Molecular Weight	360.49 g/mol
Synonyms	Iloprost (16S-isomer); 5-[(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-δ²(1H)-pentalenylidene]pentanoic Acid; ZK 36374; Ciloprost; Ilomedin; Ventavis (related to racemic drug product); (Z)-5-[(3aR,4R,5R,6aS)-5-Hydroxy-4-((S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic Acid
EINECS	Contact for details

Quality Control

Our 16(S)-Iloprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.