Description

16(R)-Iloprost is a high-purity, stereochemically defined isomer of the synthetic prostacyclin analog Iloprost, identified by CAS NO 74843-13-3. This compound is a critical reference standard and active pharmaceutical ingredient (API) intermediate for advanced pharmaceutical research and development. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focusing on cardiovascular therapeutics, pulmonary arterial hypertension (PAH) treatments, and novel drug discovery programs.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, purity assessment, and quantification of Iloprost-related substances in analytical methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of Iloprost API for final drug product formulation.
• Cardiovascular Research: Employed in preclinical and clinical studies investigating vasodilation, platelet aggregation inhibition, and cytoprotective effects.
• Pulmonary Arterial Hypertension (PAH) Drug Development: A crucial component in the R&D of therapies aimed at treating PAH and other related pulmonary vascular diseases.
• Cell Culture & In Vitro Studies: Utilized in biological assays to study prostaglandin receptor activity, signaling pathways, and endothelial cell function.
• Process Development & Validation: Applied in the development and validation of synthetic routes, purification processes, and stability-indicating analytical methods within GMP environments.

Basic Information

Product Name	16(R)-Iloprost
CAS No.	74843-13-3
Molecular Formula	C₂₂H₃₂O₄
Molecular Weight	360.49 g/mol
Synonyms	16(R)-Iloprost; (5Z)-5-{(3aR,4R,5R,6aS)-5-Hydroxy-4-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]hexahydro-2H-cyclopenta[b]furan-2-ylidene}pentanoic Acid; Iloprost Impurity F; 16R-Iloprost; ZK 36374 (16R-isomer); UNII-8L6286ST5G (16R-isomer)
EINECS	Contact for details

Quality Control

Our 16(R)-Iloprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The material is hygroscopic; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (16R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.