Description

n-[(3A,5B,7A,12A)-3,7-Dihydroxy-24-Oxo-12-(Sulfooxy)Cholan-24-Yl]-Glycine is a high-purity, chemically defined bile acid derivative, specifically a glycine conjugate of a sulfated and oxidized cholic acid analog. This compound is critical for advanced research and development in pharmaceutical chemistry, particularly in the study of metabolic pathways and receptor interactions. It serves as a key intermediate or reference standard for scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent sectors.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel therapeutic agents targeting liver and metabolic diseases.
• Biochemical Research: Acts as a critical reference standard or ligand in studies of bile acid transporters (e.g., ASBT, NTCP) and nuclear receptors (e.g., FXR, TGR5).
• Diagnostic Reagent Development: Employed in the formulation of calibration standards and assay components for clinical diagnostics related to liver function and bile acid metabolism.
• Metabolite Standard: Serves as an analytical standard in LC-MS/MS and HPLC methods for the quantification of bile acid profiles in biological samples.
• Enzyme Substrate/Inhibitor Studies: Utilized in enzymatic assays to investigate the activity of sulfotransferases, hydroxysteroid dehydrogenases, and other modifying enzymes.

Basic Information

Product Name	n-[(3A,5B,7A,12A)-3,7-Dihydroxy-24-Oxo-12-(Sulfooxy)Cholan-24-Yl]-Glycine
CAS No.	74723-17-4
Molecular Formula	C₂₆H₄₁NO₁₀S
Molecular Weight	559.68 g/mol
Synonyms	Glycocholic acid sulfate; 12-Sulfoglycocholic acid; 3α,7α-Dihydroxy-12α-sulfooxy-5β-cholan-24-oic acid N-(carboxymethyl)amide; Tauro-12-sulfolithocholic acid glycine conjugate (related); 12-O-Sulfoglycocholate; Glycine-conjugated cholic acid sulfate ester; (3α,5β,7α,12α)-3,7-Dihydroxy-12-(sulfooxy)-24-oxocholan-24-yl]glycine
EINECS	Contact for details

Quality Control

Our n-[(3A,5B,7A,12A)-3,7-Dihydroxy-24-Oxo-12-(Sulfooxy)Cholan-24-Yl]-Glycine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.