Description

Ingenol-3-Propionate-20-Isobutyrate is a semi-synthetic ingenane diterpenoid derivative of significant interest in advanced pharmaceutical research. This compound matters for its role as a key intermediate in the development of novel therapeutic agents, particularly in dermatology and oncology. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing innovative drug candidates and high-purity reference standards.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, especially those targeting specific cellular pathways.
• Biochemical Research: Used as a reference standard and probe compound in pharmacological studies to investigate protein kinase C (PKC) modulation and related signaling mechanisms.
• Dermatological R&D: Investigated for potential applications in the development of topical treatments for various skin conditions.
• Oncology Research: Employed in preclinical studies exploring the anti-proliferative and pro-apoptotic effects of ingenol derivatives on cancer cell lines.
• Fine Chemical Synthesis: Utilized as a specialized starting material or intermediate for the custom synthesis of complex, high-value molecules.
• Analytical Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories using techniques like HPLC and LC-MS.

Basic Information

Item	Detail
Product Name	Ingenol-3-Propionate-20-Isobutyrate
CAS No.	74690-92-9
Molecular Formula	C28H38O6
Molecular Weight	470.60 g/mol
Synonyms	Ingenol 3-propionate 20-isobutyrate; 20-Isobutyryloxyingenol 3-propionate; Ingenol-3-propionate-20-isobutyrate; 3-Propionyl-20-isobutyryloxyingenol; (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5-(2-Methylpropanoyloxy)-1a,2,5,5a,6,9,10,10a-octahydro-6-propionyloxy-5,5a,6,9,9-pentamethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one; Ingenol ester derivative; PEP005 derivative
EINECS	Contact for details

Quality Control

Our Ingenol-3-Propionate-20-Isobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.