Description

Rac 4-Hydroxy-3-Methoxyphenylethylene Glycol-D3 is a deuterium-labeled analog of a key metabolite in the catecholamine pathway, specifically designed for use as an internal standard in analytical chemistry. This compound is essential for ensuring the accuracy and precision of quantitative analyses, particularly in mass spectrometry, by correcting for variations in sample preparation and instrument response. It is primarily utilized by research institutions, pharmaceutical companies, and clinical diagnostic laboratories engaged in neurochemical research, drug metabolism studies, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous catecholamine metabolites like MHPG (3-Methoxy-4-hydroxyphenylethylene glycol) in biological matrices such as plasma, urine, and cerebrospinal fluid.
• Neurochemical Research: Used in studies investigating neurotransmitter metabolism, neurological disorders (e.g., depression, anxiety, Parkinson's disease), and the effects of psychotropic drugs.
• Pharmacokinetic & Drug Metabolism Studies: Enables precise tracking of drug candidates and their metabolites that interact with or affect the noradrenergic and adrenergic systems.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity assays for diagnosing and monitoring conditions related to catecholamine imbalance.
• Biomarker Analysis: Facilitates the discovery and validation of metabolic biomarkers in various disease states by providing a stable isotopic reference.
• Quality Control in Pharmaceutical Manufacturing: Employed in analytical methods to ensure the consistency and purity of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Rac 4-Hydroxy-3-Methoxyphenylethylene Glycol-D3
CAS No.	74495-72-0
Molecular Formula	C9H9D3O4
Molecular Weight	187.20 g/mol
Synonyms	DL-3-Methoxy-4-hydroxyphenylethylene glycol-d3; (±)-MHPG-d3; rac MHPG-d3; 4-Hydroxy-3-methoxyphenylethanol-d3; 1-(4-Hydroxy-3-methoxyphenyl)-1,2-ethanediol-1,1,2-d3; Deuterated MHPG; D3-MHPG; Internal Standard for MHPG
EINECS	Contact for details

Quality Control

Our Rac 4-Hydroxy-3-Methoxyphenylethylene Glycol-D3 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and the absence of interfering impurities. We adhere to relevant industry standards for research chemicals, and custom synthesis to meet specific purity or enrichment specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.