Description

Benzene, 1-Fluoro-2-Methyl-4-(Trifluoromethyl)- is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluoro substituents, which are critical for modulating the lipophilicity, metabolic stability, and electronic properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core structure in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving charge transport and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution to construct complex, value-added fluorinated compounds.

Basic Information

Product Name	Benzene, 1-Fluoro-2-Methyl-4-(Trifluoromethyl)-
CAS No.	74483-52-6
Molecular Formula	C8H6F4
Molecular Weight	178.13 g/mol
Synonyms	1-Fluoro-2-methyl-4-(trifluoromethyl)benzene; 2-Methyl-α,α,α,4-tetrafluorotoluene; 4-(Trifluoromethyl)-2-fluorotoluene; 2-Fluoro-α,α,α-trifluoro-p-xylene; 2-Fluoro-α,α,α-trifluoro-4-methylbenzene; 4-Methyl-3-(trifluoromethyl)fluorobenzene; 2-Methyl-1-fluoro-4-trifluoromethylbenzene
EINECS	Contact for details

Quality Control

Our Benzene, 1-Fluoro-2-Methyl-4-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.30 g/mL
Refractive Index (n20D)	~1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.