Description

3-Chloro-4-Methylbenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a chloro and a trifluoromethyl substituent, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethylphenyl moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups contribute to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Dye & Pigment Intermediate: Utilized in the synthesis of complex, high-performance dyes and pigments for various industrial applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for constructing complex biaryl structures in medicinal chemistry.

Basic Information

Item	Detail
Product Name	3-Chloro-4-Methylbenzotrifluoride
CAS No.	74483-47-9
Molecular Formula	C8H6ClF3
Molecular Weight	194.58 g/mol
Synonyms	1-Chloro-2-methyl-5-(trifluoromethyl)benzene; 3-Chloro-α,α,α-trifluoro-p-xylene; 2-Methyl-5-(trifluoromethyl)chlorobenzene; 3-Chloro-4-methyl-α,α,α-trifluorotoluene; 5-Chloro-2-methylbenzotrifluoride; 3-Chloro-4-methylbenzyltrifluoride; 3-Chloro-4-methyl-1-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Methylbenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global clientele in fine chemical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (20°C)	~1.35 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.