Description

2-Toluic Acid Glucuronide is a key glucuronide metabolite of o-toluic acid, representing a crucial phase II biotransformation product. This compound is essential for researchers and developers in the fields of drug metabolism and pharmacokinetics (DMPK), toxicology, and analytical chemistry. It serves as a vital reference standard for method development, validation, and the study of metabolic pathways in pharmaceutical and life science applications.

Application

• Pharmaceutical Reference Standard: Primary use as a certified standard for quantitative analysis in bioanalytical studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Used to investigate and validate the glucuronidation metabolic pathway of drug candidates and related substances.
• Toxicology Studies: Employed as a biomarker or reference compound in studies assessing the metabolism and excretion of toluene derivatives.
• Analytical Method Development: Critical for developing and calibrating HPLC, LC-MS, and other chromatographic methods for metabolite detection.
• Biochemical Research: Tool for studying the activity and specificity of UDP-glucuronosyltransferase (UGT) enzymes.
• Quality Control: Serves as an impurity marker or system suitability standard in the quality control of pharmaceutical active ingredients.

Basic Information

Product Name	2-Toluic Acid Glucuronide
CAS No.	74389-92-7
Molecular Formula	C14H16O8
Molecular Weight	312.27 g/mol
Synonyms	o-Toluic Acid Glucuronide; 2-Methylbenzoic Acid Glucuronide; (2-Methylbenzoyl)-β-D-glucopyranosiduronic Acid; 1-O-(2-Methylbenzoyl)-β-D-glucopyranuronic Acid; o-Toluoylglucuronide; 2-Methylbenzoyl-β-D-glucuronide; Glucuronide of o-Toluic Acid
EINECS	Contact for details

Quality Control

Our 2-Toluic Acid Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.