Description

Leuprorelin Acetate CAS NO 74381-53-6 is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH). This compound is a critical active pharmaceutical ingredient (API) valued for its potent and specific hormonal activity. It is primarily required by the pharmaceutical industry for the formulation of advanced therapeutic treatments in oncology and endocrinology.

Application

• Pharmaceutical API: Core active ingredient in injectable formulations for the treatment of hormone-responsive cancers such as advanced prostate cancer and breast cancer.
• Endocrine Disorder Therapy: Used in medications for managing conditions like endometriosis, uterine fibroids, and central precocious puberty.
• Controlled-Release Drug Delivery: Essential component in the manufacture of long-acting depot injections and implantable devices.
• Veterinary Pharmaceuticals: Applied in veterinary medicine for the chemical castration and hormonal regulation of animals.
• Research & Development: Serves as a key reference standard and biochemical tool in pharmacological and endocrinological research.
• Bioconjugation & Peptide Chemistry: Used as a starting material or intermediate in the synthesis of more complex peptide-drug conjugates.

Basic Information

Item	Detail
Product Name	Leuprorelin Acetate
CAS No.	74381-53-6
Molecular Formula	C59H84N16O12 • (C2H4O2)x
Molecular Weight	1209.41 (free base)
Synonyms	Leuprolide Acetate; Leuprorelin; Abbott-43818; 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (pig) acetate salt; GnRH Agonist Leuprorelin; TAP-144; Leuprorelin acetate salt; Leuprorelin monoacetate
EINECS	Contact for details

Quality Control

Our Leuprorelin Acetate is manufactured under strict quality management systems. Each batch is tested to meet high-purity pharmacopeial standards, including identification, assay, and impurity profiles via advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, residual solvents, and microbiological data is provided with every shipment to ensure full traceability and compliance for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 10.0 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.