Description

4-(Phosphonoacetyl)-L-α-Aminobutyrate is a specialized phosphonic acid derivative of an amino acid, serving as a critical intermediate in advanced organic synthesis. Its unique structure, featuring both phosphonoacetyl and L-aminobutyrate moieties, makes it a valuable building block for creating complex molecules with targeted biological activity. This compound is primarily utilized by research institutions and pharmaceutical developers focused on metabolic pathway modulation and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of enzyme inhibitors and other bioactive compounds targeting metabolic disorders.
• Biochemical Research: Used as a substrate analog or inhibitor in enzymatic studies, particularly those involving phosphonate metabolism or amino acid processing.
• Peptidomimetic Synthesis: Serves as a constrained, phosphonate-containing building block for designing peptide analogs with enhanced stability and specificity.
• Agrochemical Development: Potential intermediate for creating novel herbicides or plant growth regulators that mimic natural amino acid antimetabolites.
• Chemical Biology Probes: Utilized in the development of activity-based probes to study specific enzyme families in complex biological systems.

Basic Information

Product Name	4-(Phosphonoacetyl)-L-α-Aminobutyrate
CAS No.	74317-96-7
Molecular Formula	C6H12NO7P
Molecular Weight	241.14 g/mol
Synonyms	L-2-Amino-4-(phosphonoacetyl)butyric acid; (2S)-2-Amino-4-(phosphonoacetyl)butanoic acid; 4-(Phosphonoacetyl)-L-2-aminobutanoate; Phosphonoacetyl-L-homoserine analog; PAA-L-AB; 74317-96-7; 4-Phosphonoacetyl-L-aminobutyric acid
EINECS	Contact for details

Quality Control

Our 4-(Phosphonoacetyl)-L-α-Aminobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and ICP-MS for heavy metal screening, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% L-isomer
Water Content (KF)	≤ 2.0%
Heavy Metals (ICP-MS)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.