Description

Bis(Methylthio)Gliotoxin is a chemically modified derivative of the fungal mycotoxin gliotoxin, characterized by the addition of two methylthio groups. This structural modification is of significant interest in biochemical and pharmaceutical research, particularly in the study of cellular redox processes and apoptosis. It serves as a critical reference standard and a key intermediate for researchers and developers in the fields of mycotoxin analysis, medicinal chemistry, and molecular biology.

Application

• Biochemical Research: Used as a reference standard and tool compound for studying the biological activity and mechanisms of gliotoxin derivatives.
• Pharmaceutical Development: Serves as a key synthetic intermediate or precursor in the research and development of novel therapeutic agents.
• Analytical Chemistry: Employed as a certified reference material (CRM) for the calibration and validation of analytical methods, such as HPLC and LC-MS, in mycotoxin detection.
• Toxicology Studies: Utilized in research to investigate the structure-activity relationships and toxicological profiles of epipolythiodioxopiperazine (ETP) class metabolites.
• Academic Research: A vital reagent for universities and research institutions exploring fungal metabolism, natural product synthesis, and cellular signaling pathways.

Basic Information

Product Name	Bis(Methylthio)Gliotoxin
CAS No.	74149-38-5
Molecular Formula	C13H14N2O4S2
Molecular Weight	326.39 g/mol
Synonyms	Bis(methylthio)gliotoxin; 3,6-Bis(methylthio)-3,6-dihydroxy-2,5-dioxopiperazine; Gliotoxin, bis(methylthio)-; 3,6-Epidithio-3,6-dihydroxy-2,5-dioxopiperazine, bis(methylthio) derivative; ETP derivative; Dithiogliotoxin derivative
EINECS	Contact for details

Quality Control

Our Bis(Methylthio)Gliotoxin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and spectroscopic methods for structural verification (IR, NMR). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.