Description

Tunicamycin D1) CAS NO 73942-08-2 is a specific, high-purity congener of the tunicamycin complex, a well-characterized nucleoside antibiotic. This compound is a critical research tool valued for its potent and specific inhibition of N-linked glycosylation in eukaryotic cells. It is primarily utilized by researchers and developers in the life sciences, biotechnology, and pharmaceutical industries for applications ranging from fundamental cell biology studies to drug discovery and development.

Application

• Biomedical Research: Used as a selective inhibitor to study protein glycosylation pathways, endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in cell culture models.
• Antiviral Research: Investigated for its potential to inhibit the glycosylation of viral envelope proteins, which is crucial for the infectivity of many viruses.
• Cancer Research: Employed to explore the role of glycosylation in tumor progression, metastasis, and resistance to chemotherapy.
• Drug Discovery: Serves as a pharmacological tool in high-throughput screening assays to identify novel compounds that modulate glycosylation or ER stress pathways.
• Biochemical Studies: Utilized in vitro to study the mechanism of action of the enzyme GlcNAc phosphotransferase.
• Agricultural Research: Applied in studies targeting plant pathogen resistance by inhibiting essential glycosylation processes in fungi or other pests.

Basic Information

Product Name	Tunicamycin D1) CAS NO 73942-08-2
CAS No.	73942-08-2
Molecular Formula	C39H64N4O16
Molecular Weight	844.95 g/mol
Synonyms	Tunicamycin D1; Tunicamycin V; Antibiotic MM 19290; Homomycin B1; Tunicamycin complex component D1; Streptomyces lysosuperificus antibiotic; Nucleoside antibiotic tunicamycin D1; N-Acetylglucosaminyltunicamycin; 1-[(2R,3R,4S,5S,6R)-4-[(2R,3R,4S,5R)-4-[(2R,3S,4R,5R,6S)-3-Acetamido-6-[(1R)-1,2-dihydroxyethyl]-4,5-dihydroxyoxan-2-yl]oxy-2,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]-3-hydroxyundec-4-enamide
EINECS	Contact for details

Quality Control

Our Tunicamycin D1 is produced under stringent quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification via spectroscopic methods. Certificates of Analysis (COA) detailing purity, potency, and related substances are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Conforms to reference (Inhibits protein glycosylation)
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.