Description

Tunicamycin C2 Homolog CAS NO 73942-07-1 is a specific, naturally occurring homolog of the tunicamycin antibiotic complex, characterized by its C2 fatty acyl side chain. This compound is a potent and selective inhibitor of N-linked glycosylation, a critical post-translational modification process in eukaryotic cells. It is an essential biochemical tool for researchers in life sciences, particularly for those studying protein processing, endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in cell biology and pharmacology.

Application

• Biochemical Research: A critical tool for inhibiting N-linked protein glycosylation in cell culture and in vitro studies to investigate protein folding, trafficking, and function.
• Cell Biology Studies: Used to induce ER stress and activate the UPR pathway, enabling research into cellular stress responses, apoptosis, and related disease mechanisms.
• Antiviral Research: Explored for its potential to inhibit the glycosylation of viral envelope proteins, which can disrupt viral assembly and infectivity.
• Cancer Research: Employed in studies examining how disruption of glycosylation affects cancer cell proliferation, metastasis, and sensitivity to therapeutics.
• Glycobiology: Serves as a standard or reference compound in studies dedicated to understanding the biosynthesis and biological roles of glycoproteins.
• Pharmacology & Toxicology: Used to model glycosylation inhibition and study its downstream effects on cell viability and organelle function.

Basic Information

Product Name	Tunicamycin C2 Homolog
CAS No.	73942-07-1
Molecular Formula	C39H64N4O16
Molecular Weight	844.95 g/mol
Synonyms	Tunicamycin C2; Tunicamycin II; Antibiotic MM 19290; Homotunicamycin; Tunicamycin C; Tunicamycin complex component C2; Streptomyces lysosuperificus antibiotic; N-Glycosylation inhibitor C2 homolog
EINECS	Contact for details

Quality Control

Our Tunicamycin C2 Homolog is produced under stringent conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing purity, potency, and analytical data is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Conforms (Inhibits N-linked glycosylation)
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.