Description

Iloprost is a synthetic analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This high-purity active pharmaceutical ingredient (API) is critical for developing advanced therapies targeting pulmonary arterial hypertension (PAH) and other severe vascular disorders. It is essential for pharmaceutical manufacturers and research institutions engaged in the development of innovative cardiovascular and pulmonary medicines. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency and reliability for critical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in medications for treating pulmonary arterial hypertension (PAH).
• Vascular Research: A key tool in preclinical and clinical research studying vasodilation, platelet function, and endothelial cell protection.
• Drug Delivery Development: Used in formulating inhalable, intravenous, and oral dosage forms to optimize therapeutic efficacy and patient compliance.
• Cardioprotective Agent Studies: Investigated in research models for ischemia-reperfusion injury, Raynaud's phenomenon, and systemic sclerosis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Cell Culture & Biochemistry: Utilized in vitro to study prostaglandin signaling pathways and their effects on smooth muscle and vascular cells.

Basic Information

Product Name	Iloprost
CAS No.	73873-87-7
Molecular Formula	C₂₂H₃₂O₄
Molecular Weight	360.49 g/mol
Synonyms	ZK 36374; Ilomedin; 5-{(E)-(1S,5S,6R,7R)-7-Hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octan-3-ylidene}pentanoic Acid; Ciloprost; (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-δ⁶α,δ²-pentalenevaleric Acid; Prostacyclin PGI2 analog; Ventavis (brand name formulation)
EINECS	Contact for details

Quality Control

Our Iloprost is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and stringent control of related substances and residual solvents. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic nature, the container must be kept in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.