Description

(+/-)-Mevalonolactone-1-13C CAS NO 73834-54-5 is a stable isotope-labeled analog of mevalonolactone, where the carbon-13 isotope is incorporated at the 1-position. This compound is a critical intermediate in the biosynthesis of isoprenoids and sterols, serving as a vital tracer in metabolic pathway research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for advanced analytical and diagnostic applications.

Application

• Metabolic Pathway Tracing: Used as a labeled precursor in in vitro and in vivo studies to elucidate the mevalonate pathway and cholesterol biosynthesis.
• Stable Isotope Dilution Mass Spectrometry (SID-MS): Serves as an internal standard for the highly accurate quantification of mevalonic acid and related metabolites in biological samples.
• Pharmaceutical R&D: Employed in the development and testing of drugs targeting HMG-CoA reductase and other enzymes in the isoprenoid synthesis pathway.
• Biochemical Research: A key tool for studying enzyme kinetics, metabolic flux analysis, and the regulation of sterol and non-sterol isoprenoid production.
• Diagnostic Assay Development: Used in the formulation of calibration standards and controls for clinical assays measuring metabolic disorders.

Basic Information

Item	Detail
Product Name	(+/-)-Mevalonolactone-1-13C
CAS No.	73834-54-5
Molecular Formula	C6H1013CO3
Molecular Weight	131.12 g/mol (for 13C1 labeled form)
Synonyms	DL-Mevalonolactone-1-13C; (±)-Mevalonolactone-1-13C; 3-Hydroxy-3-methyl-5-valerolactone-1-13C; 5,6-Dihydro-6-methyl-2H-pyran-2-one-1-13C; Mevalolactone-1-13C; 6-Methyltetrahydro-2H-pyran-2-one-1-13C; 3-Methyl-5-valerolactone-1-13C; 3-Hydroxy-3-methylpentanoic acid δ-lactone-1-13C
EINECS	Contact for details

Quality Control

Our (+/-)-Mevalonolactone-1-13C is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and Mass Spectrometry, to confirm isotopic enrichment, chemical purity, and identity. Certificates of Analysis (COA) detailing the isotopic purity (atom % 13C), chemical purity, and specific tests are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Chemical Purity (NMR)	≥ 98%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.