Description

4-(p-Trifluoroacetylaminophenyl)Butyric Acid Methyl Ester is a high-purity, specialized organic intermediate featuring a trifluoroacetyl-protected aniline moiety. This compound is valued for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Peptide Mimetics & PROTACs: Employed in medicinal chemistry for creating peptide analogs and Proteolysis-Targeting Chimeras (PROTACs) due to its amide-like structure and lipophilicity.
• Fluorine Chemistry Research: An essential reagent for introducing the trifluoroacetylaminophenyl group into molecular scaffolds in academic and industrial fluorine chemistry labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-(p-Trifluoroacetylaminophenyl)Butyric Acid Methyl Ester
CAS No.	73747-24-7
Molecular Formula	C14H14F3NO3
Molecular Weight	301.26 g/mol
Synonyms	Methyl 4-[4-(Trifluoroacetylamino)phenyl]butyrate; 4-(4-(Trifluoroacetamido)phenyl)butanoic acid methyl ester; p-Trifluoroacetamidophenylbutyric Acid Methyl Ester; 4-(4-Trifluoroacetylamino-phenyl)-butyric acid methyl ester; Methyl 4-(4-(trifluoroacetamido)phenyl)butanoate; N-[4-(3-Methoxy-3-oxopropyl)phenyl]-2,2,2-trifluoroacetamide; 73747-24-7 (CAS Name)
EINECS	Contact for details

Quality Control

Our 4-(p-Trifluoroacetylaminophenyl)Butyric Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure compliance with research and production-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.