Description

Primidone-D5 is a deuterated internal standard of the anticonvulsant drug Primidone, specifically designed for analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic science industries, where precise measurement of Primidone levels is required.

Application

• Internal Standard for LC-MS/MS and GC-MS: Used as a quantitative reference in mass spectrometry to correct for analyte loss during sample preparation and instrument variability.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking and measurement of Primidone and its metabolites in biological fluids (plasma, serum, urine).
• Therapeutic Drug Monitoring (TDM): Critical for developing and validating assays to monitor Primidone concentrations in patient samples for optimal dosing.
• Drug Metabolism and Disposition Research: Facilitates studies on the metabolic pathways and clearance rates of Primidone.
• Forensic and Toxicology Analysis: Provides a reliable standard for the detection and quantification of Primidone in forensic investigations.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of Primidone in active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	Primidone-D5
CAS No.	73738-06-4
Molecular Formula	C12H9D5N2O2
Molecular Weight	221.27 g/mol
Synonyms	5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione-d5; 5-Ethyl-5-phenyl-d5-hexahydropyrimidine-4,6-dione; Primidone (phenyl-d5); Primidone-d5 (ethyl-d5, phenyl-d5); Primidone (ethyl-d5, phenyl-d5); 2-Desoxyphenobarbital-d5; Liskantin-d5; Mysoline-d5
EINECS	Contact for details

Quality Control

Our Primidone-D5 is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing these specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.