Description

(-)-Bicuculline Methobromide is a potent and selective competitive antagonist of the GABAA receptor, widely recognized as a crucial pharmacological tool in neuroscience research. This compound is essential for studying inhibitory neurotransmission, synaptic plasticity, and the mechanisms underlying various neurological disorders. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic laboratories focused on neuropharmacology and central nervous system drug discovery.

Application

• Neuroscience Research: Fundamental tool for investigating GABAergic inhibition, neuronal excitability, and receptor function in in vitro and ex vivo models.
• Pharmacological Studies: Used to characterize and validate new compounds targeting the GABAA receptor in drug discovery pipelines.
• Electrophysiology: Critical for patch-clamp experiments to block GABA-induced currents and study synaptic transmission.
• Disease Model Research: Applied in studies of epilepsy, anxiety, insomnia, and other disorders linked to GABAergic system dysfunction.
• Biochemical Assays: Serves as a reference standard in receptor binding assays and other biochemical screenings.

Basic Information

Product Name	(-)-Bicuculline Methobromide
CAS No.	73604-30-5
Molecular Formula	C21H20BrNO6
Molecular Weight	462.29 g/mol
Synonyms	(-)-Bicuculline Methobromide; Bicuculline Methobromide; (S)-(-)-Bicuculline Methobromide; NSC 224994; 1(S),9(R)-Bicuculline Methobromide; (1S,9R)-6-[(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one Methobromide
EINECS	Contact for details

Quality Control

Our (-)-Bicuculline Methobromide is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.