Description

(Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,S)-3-Hydroxy-4-[3-(Trifluoromethyl)Phenoxy]-1-Butenyl]Cyclopentan-1α-Yl]-2-Heptenoic Acid is a high-purity synthetic prostaglandin analog, a key advanced pharmaceutical intermediate. Its complex stereochemistry and trifluoromethylphenoxy moiety make it a critical building block for the development of potent, targeted therapeutic agents. This compound is essential for research and manufacturing in the pharmaceutical industry, particularly for projects focused on cardiovascular, ocular, and inflammatory pathways.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral synthon in the synthesis of novel prostaglandin-based drugs.
• Ophthalmic Drug Development: Research and production of prostaglandin analogs for glaucoma treatment (e.g., latanoprost, travoprost analogs).
• Cardiovascular Research: Investigation of vasoactive properties and development of compounds targeting vascular tone and platelet aggregation.
• Inflammatory Mediator Studies: Used in biochemical research to study prostaglandin receptors and pathways involved in inflammation.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and starting material for process optimization and GMP manufacturing.
• Academic & Institutional Research: A valuable tool for synthetic organic chemistry and medicinal chemistry programs in universities and R&D institutes.

Basic Information

Product Name	(Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,S)-3-Hydroxy-4-[3-(Trifluoromethyl)Phenoxy]-1-Butenyl]Cyclopentan-1α-Yl]-2-Heptenoic Acid
CAS No.	73307-38-7
Molecular Formula	C23H29F3O6
Molecular Weight	458.47 g/mol
Synonyms	Fluprostenol Impurity; Travoprost Related Compound; 17-Phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester analog; 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-2-heptenoic Acid; Prostaglandin F2α Trifluoromethyl Phenoxy Derivative; (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-4-(3-trifluoromethylphenoxy)but-1-enyl]cyclopentyl]hept-5-enoic Acid; AL-6221 (related compound); Fluprostenol free acid.
EINECS	Contact for details

Quality Control

Our (Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,S)-3-Hydroxy-4-[3-(Trifluoromethyl)Phenoxy]-1-Butenyl]Cyclopentan-1α-Yl]-2-Heptenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.