Description

(Z)-7-[(1R)-2β-[(E,S)-3-Hydroxy-4-(1-Cyclohexen-1-Ylthio)-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is a high-purity, synthetically produced prostaglandin analog intermediate of significant importance in advanced pharmaceutical synthesis. Its complex stereochemistry and functional groups make it a critical building block for the development of potent therapeutic agents targeting specific physiological pathways. This compound is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the development of novel prostaglandin-based drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of advanced prostaglandin and prostacyclin analogs for clinical research and development.
• Biochemical Research: Used as a reference standard and precursor in studies investigating the role of prostaglandins in inflammation, vascular tone, and reproductive biology.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at discovering new drug candidates with improved potency and selectivity.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for prostaglandin-based active pharmaceutical ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Item	Detail
Product Name	(Z)-7-[(1R)-2β-[(E,S)-3-Hydroxy-4-(1-Cyclohexen-1-Ylthio)-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester
CAS No.	73285-92-4
Molecular Formula	C23H34O5S
Molecular Weight	422.58 g/mol
Synonyms	Methyl (Z)-7-[(1R,2R,3R,5S)-2-[(E,3S)-3-Hydroxy-4-(1-cyclohexen-1-ylthio)-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoate; 9-Deoxy-9-methylene-16-phenoxy-tetranor PGE2 derivative; Prostaglandin F2α analog intermediate; 16-(m-Trifluoromethylphenoxy)-tetranor PGF2α methyl ester precursor; Latanoprost intermediate; Isopropyl ester analog intermediate; 17-Phenyl-18,19,20-trinor PGF2α methyl ester.
EINECS	Contact for details

Quality Control

Our (Z)-7-[(1R)-2β-[(E,S)-3-Hydroxy-4-(1-Cyclohexen-1-Ylthio)-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings (e.g., FDA DMF, CEP).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This compound is easily oxidized; for long-term storage, consider under an inert atmosphere (argon or nitrogen) in a sealed container. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.