Description

(Z)-7-[(1R)-2β-[(E,S)-3-(2-Benzofuranyl)-3-Hydroxy-1-Propenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is a high-purity synthetic prostaglandin intermediate with a complex stereochemistry critical for biological activity. This compound is essential for pharmaceutical research and development, serving as a key building block in the synthesis of advanced therapeutic agents. It is primarily required by R&D laboratories and manufacturers in the pharmaceutical and life sciences sectors focusing on cardiovascular, ocular, and inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of prostaglandin-based active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of novel drug candidates targeting prostaglandin receptors.
• Ophthalmic Drug Synthesis: Key starting material for the production of prostaglandin analogues used in glaucoma treatments (e.g., analogues of Latanoprost or Bimatoprost).
• Cardiovascular Research: Employed in the development of compounds that modulate vascular tone and platelet aggregation.
• Biochemical Research: Serves as a standard or reference material in analytical studies of eicosanoid pathways and lipid mediators.
• Process Chemistry & Scale-Up: Utilized for optimizing synthetic routes and scaling production from laboratory to pilot and commercial scales.

Basic Information

Item	Detail
Product Name	(Z)-7-[(1R)-2β-[(E,S)-3-(2-Benzofuranyl)-3-Hydroxy-1-Propenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester
CAS No.	73285-87-7
Molecular Formula	C26H32O6
Molecular Weight	440.53 g/mol
Synonyms	Methyl (Z)-7-[(1R,2R,3R,5S)-2-[(E,3S)-3-(Benzofuran-2-yl)-3-hydroxyprop-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoate; 17-Phenyl-18,19,20-trinorprostaglandin F2α methyl ester (isomer); Prostaglandin F2α analogue intermediate; 7-[(1R,2R,3R,5S)-2-[(E,3S)-3-(1-Benzofuran-2-yl)-3-hydroxyprop-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid methyl ester; PGF2α Type Intermediate; Bimatoprost/Latanoprost Intermediate; Contact for details on additional aliases.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support compliance with ICH Q7 guidelines and can tailor specifications to meet the requirements of your drug master file (DMF) or regulatory submission.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.