Description

(2E,5Z)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-2,5-Heptadienoic Acid CAS NO 73275-75-9 is a high-purity, complex prostaglandin analog with significant biological activity. This compound is a critical advanced pharmaceutical intermediate used in the research and development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers focused on cardiovascular, ophthalmic, and anti-inflammatory drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel prostaglandin-based drugs targeting intraocular pressure (glaucoma), pulmonary arterial hypertension, and ulcer healing.
• Biochemical Research: Used as a reference standard and active agent in pharmacological studies to investigate prostaglandin receptor (EP, FP) interactions and signaling pathways.
• Process Chemistry Development: Serves as a critical intermediate for process chemists scaling up the production of prostaglandin active pharmaceutical ingredients (APIs).
• Cell Culture & In Vitro Studies: Employed in cell-based assays to study its effects on smooth muscle contraction, inflammation, and cellular proliferation.

Basic Information

Product Name	(2E,5Z)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-2,5-Heptadienoic Acid
CAS No.	73275-75-9
Molecular Formula	C22H27ClO6
Molecular Weight	422.90 g/mol
Synonyms	Prostaglandin F2α analog; 17-Phenyl trinor Prostaglandin F2α derivative; 3-Chlorophenoxy Prostaglandin Intermediate; Travoprost Related Compound; AL-8810 (research code); 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-2,5-heptadienoic Acid; (Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoic Acid
EINECS	Contact for details

Quality Control

Our (2E,5Z)-7-[(1R)-2β-[(E,R)-4-(3-Chlorophenoxy)-3-Hydroxy-1-Butenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-2,5-Heptadienoic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC purity, chiral purity, and identity confirmation, to ensure it meets exacting standards for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.