Description

(E)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is a high-purity synthetic prostaglandin intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the synthesis of advanced therapeutic agents, particularly those targeting ocular and cardiovascular systems. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel prostaglandin-based drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of prostaglandin analogs like Latanoprost, Bimatoprost, and Travoprost.
• Ophthalmic Drug Development: Used in research and production of medications for glaucoma and ocular hypertension.
• Cardiovascular Research: Employed in studies related to vasodilation and platelet aggregation.
• Chemical Synthesis: Serves as a versatile chiral synthon for constructing complex, biologically active molecules.
• Process Development & Scale-up: Critical for optimizing manufacturing routes for prostaglandin active pharmaceutical ingredients (APIs).
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical labs.

Basic Information

Item	Details
Product Name	(E)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester
CAS No.	73275-73-7
Molecular Formula	C23H32O6
Molecular Weight	404.50 g/mol
Synonyms	Methyl (5Z,13E,15S)-9α,11α,15-Trihydroxy-17-phenyl-18,19,20-trinorprosta-5,13-dien-1-oate; Latanoprost Intermediate; Prostaglandin F2α Methyl Ester Derivative; 17-Phenyl-18,19,20-trinor-PGF2α Methyl Ester; Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate related intermediate; 9,11,15-Trihydroxy-17-phenyl-prosta-5,13-dien-1-oic Acid Methyl Ester; Travoprost Key Intermediate
EINECS	Contact for details

Quality Control

Our (E)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen) when not in use to prevent degradation. The storage area should be well-ventilated and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.