Description

n-Acetylpalytoxin is a potent, semi-synthetic derivative of the marine neurotoxin palytoxin, characterized by the acetylation of the parent compound. This modification is crucial for enhancing stability and enabling specific biochemical research applications where precise molecular tools are required. It is primarily utilized by advanced research institutions and pharmaceutical development laboratories focusing on neuropharmacology, ion channel studies, and the development of novel therapeutic agents or detection assays.

Application

• Biochemical Research: A critical tool for studying the structure-activity relationship (SAR) of palytoxin and its interaction with the Na+/K+-ATPase pump.
• Neuropharmacology: Used in electrophysiological studies to investigate ion channel function, modulation, and related neurological pathways.
• Toxin Standard: Serves as a certified reference material (CRM) or analytical standard in environmental monitoring and seafood safety testing for ciguatera-like poisoning.
• Pharmaceutical Development: Employed in early-stage discovery for evaluating potential antidotes or therapeutic interventions against palytoxin exposure.
• Diagnostic Assay Development: Used in the development and calibration of high-sensitivity immunoassays (e.g., ELISA) and biosensors for marine toxin detection.

Basic Information

Product Name	n-Acetylpalytoxin
CAS No.	73070-85-6
Molecular Formula	C₁₂₉H₂₂₃N₃O₅₄
Molecular Weight	~2680.2 g/mol
Synonyms	Acetylpalytoxin; Palytoxin acetate; N-Acetyl-palytoxin; (3S,4R)-4-Acetamido-3-[(2R,3R,4S,5S,6R)-4-[(2S,3S,4R,5R,6S)-6-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-2-methylbutanoic acid (IUPAC); Marine toxin derivative
EINECS	Contact for details

Quality Control

Our n-Acetylpalytoxin is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure identity and potency. Certificates of Analysis (COA) detailing batch-specific data are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container should be equilibrated to room temperature before opening to prevent condensation. Store in a dedicated, secure facility in accordance with local regulations for handling potent bioactive compounds.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.