Description

Pergolide Sulfoxide (50 Mg) is a high-purity chemical reference standard, a key metabolite of the dopamine agonist Pergolide. This compound is essential for analytical research and quality control processes, ensuring accurate identification and quantification in complex matrices. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and regulatory bodies for method development, validation, and impurity profiling.

Application

• Pharmaceutical Impurity Standard: Serves as a certified reference material for the identification and quantification of Pergolide Sulfoxide as a degradation product or metabolite in active pharmaceutical ingredient (API) and finished drug product analysis.
• Metabolite Studies: Used in pharmacokinetic and drug metabolism research to study the biotransformation pathways of Pergolide.
• Analytical Method Development: Critical for developing and validating stability-indicating HPLC, UPLC, or LC-MS/MS methods in compliance with ICH guidelines.
• Quality Control & Assurance: Employed as an external standard in routine QC testing to ensure the purity and stability of Pergolide mesylate and related formulations.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive proof of impurity structure and supporting specification setting.

Basic Information

Product Name	Pergolide Sulfoxide (50 Mg)
CAS No.	72822-01-6
Molecular Formula	C19H26N2O3S
Molecular Weight	362.49 g/mol
Synonyms	8β-[(Methylthio)methyl]-6-propylergoline-1-carboxamide S-oxide; Pergolide S-Oxide; Pergolide Sulfoxide; (8β)-6-Propyl-8-[(methylsulfinyl)methyl]ergoline-1-carboxamide; LY 127809 Sulfoxide; Permax Metabolite
EINECS	Contact for details

Quality Control

Every batch of Pergolide Sulfoxide is manufactured and controlled under a strict quality management system. The product undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications suitable for use as a reference standard.

Storage

Preserve in the originally supplied, tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.