Description

Ici-118,551 is a selective β-2 adrenergic receptor antagonist, a high-purity research chemical with the CAS number 72795-19-8. This compound is a critical pharmacological tool for investigating respiratory and cardiovascular pathways, offering researchers precise modulation of β-2 adrenergic activity. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on receptor characterization, drug discovery, and mechanistic studies.

Application

• Pharmacological Research: A standard tool compound for studying β-2 adrenergic receptor function and signaling mechanisms.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for respiratory and cardiovascular therapeutics.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays, and enzyme-linked immunosorbent assays (ELISAs).
• Academic & Institutional Research: Supports basic science investigations into asthma, COPD, and other conditions involving adrenergic pathways.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in QC laboratories.
• Preclinical Studies: Utilized in animal models to evaluate the physiological effects of β-2 adrenergic blockade.

Basic Information

Product Name	Ici-118,551
CAS No.	72795-19-8
Molecular Formula	C22H30N2O4
Molecular Weight	386.49 g/mol
Synonyms	ICI 118551; ICI-118,551; ICI-118551 Hydrochloride; Erythro-1-(7-Methylindan-4-yloxy)-3-(isopropylamino)-2-butanol; (S,S)-ICI 118551; (±)-Erythro-1-(7-methylindan-4-yloxy)-3-[(1-methylethyl)amino]-2-butanol; ICI-118551 free base; β-2 adrenergic antagonist ICI-118551
EINECS	Contact for details

Quality Control

Every batch of Ici-118,551 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring compliance with research-grade standards. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.