Description

β-Funaltrexamine is a potent and selective irreversible antagonist of the mu-opioid receptor (MOR). This compound is a critical research tool in neuropharmacology, enabling the study of opioid receptor function, signal transduction pathways, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and addiction research.

Application

• Neuroscience Research: Fundamental tool for investigating the physiological and pharmacological roles of mu-opioid receptors in the central nervous system.
• Mechanistic Studies: Used to irreversibly block MORs to study receptor turnover, downstream signaling effects, and the contributions of specific receptor populations in vivo and in vitro.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in the screening and characterization of new opioid analgesics or treatments for substance use disorders.
• Behavioral Pharmacology: Employed in animal models to dissect the mechanisms underlying opioid-induced analgesia, tolerance, dependence, and reward.
• Biochemical Assays: Used in receptor binding assays and other biochemical experiments to validate test systems and quantify receptor density.

Basic Information

Product Name	β-Funaltrexamine
CAS No.	72782-05-9
Molecular Formula	C₂₂H₂₈N₂O₅
Molecular Weight	400.47 g/mol
Synonyms	β-Funaltrexamine; β-FNA; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-yl carboxamide; (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one carboxamide; 6β-Naltrexamine; NSC 339768
EINECS	Contact for details

Quality Control

Our β-Funaltrexamine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for advanced research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.