Description

Swainsonine CAS NO 72741-87-8 is a potent indolizidine alkaloid known for its specific biological activity as an inhibitor of α-mannosidase enzymes. This high-purity compound is critical for research and development in life sciences, enabling precise biochemical studies. It is primarily sought after by pharmaceutical researchers, biotechnology companies, and academic institutions focused on glycosylation biology, oncology research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specific and potent inhibitor of Golgi α-mannosidase II in studies of N-linked glycan processing and glycoprotein function.
• Oncology & Cancer Research: Investigated for its potential anti-metastatic and anti-angiogenic properties in various cancer cell lines and animal models.
• Immunology Studies: Employed to study the role of glycosylation in immune cell function, antigen presentation, and inflammatory responses.
• Veterinary Toxicology Reference Standard: Serves as a critical analytical standard for the detection and quantification of swainsonine in plant and animal tissues, relevant to locoweed poisoning.
• Drug Discovery & Development: Acts as a lead compound or tool molecule in the search for new glycosidase inhibitors with therapeutic potential.
• Cell Biology & Glycobiology: A fundamental tool for manipulating cellular glycosylation patterns to understand their impact on protein folding, trafficking, and cell signaling.

Basic Information

Product Name	Swainsonine
CAS No.	72741-87-8
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	Swainsonine; (1S,2R,8R,8aR)-1,2,8-Trihydroxyoctahydroindolizine; (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol; 8aβ-Indolizidine-1α,2α,8β-triol; Locoine; Slaframine analog
EINECS	Contact for details

Quality Control

Our Swainsonine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality guidelines suitable for research-grade biochemicals to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	[α]20/D: -80° to -90° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.