Description

7,12-Dimethylbenz(A)Anthracene-3,4-Dihydrodiol is a high-purity dihydrodiol derivative of the polycyclic aromatic hydrocarbon (PAH) 7,12-dimethylbenz[a]anthracene (DMBA). This compound is a critical metabolic intermediate used extensively in biochemical and toxicological research to study carcinogenic pathways. It is primarily required by research institutions, pharmaceutical R&D laboratories, and contract research organizations (CROs) investigating the mechanisms of chemical carcinogenesis, metabolic activation, and DNA adduct formation.

Application

• Biochemical Research: As a key metabolite for studying the metabolic activation pathways of the potent carcinogen DMBA.
• Toxicology Studies: Used in in vitro and in vivo models to investigate the mechanisms of PAH-induced carcinogenesis and tumor initiation.
• Enzyme Activity Assays: Serves as a specific substrate for studying the activity of cytochrome P450 enzymes and epoxide hydrolase involved in procarcinogen activation.
• DNA Adduct Formation Studies: Essential for research on the formation and repair of DNA adducts, which are critical events in chemical carcinogenesis.
• Reference Standard: Used as an analytical standard in HPLC, LC-MS, and GC-MS methods for the quantification of DMBA metabolites in biological samples.
• Cancer Mechanism Research: Fundamental for elucidating the role of specific diol-epoxide intermediates in breast cancer and skin cancer models.

Basic Information

Product Name	7,12-Dimethylbenz(A)Anthracene-3,4-Dihydrodiol
CAS No.	72617-60-8
Molecular Formula	C₂₀H₁₈O₂
Molecular Weight	290.36 g/mol
Synonyms	DMBA-3,4-dihydrodiol; 3,4-Dihydroxy-3,4-dihydro-7,12-dimethylbenz[a]anthracene; 7,12-DMBA-3,4-diol; 7,12-Dimethylbenz[a]anthracene-3,4-dihydrodiol; (+/-)-7,12-Dimethylbenz[a]anthracene-3,4-dihydrodiol; 3,4-Dihydro-7,12-dimethylbenz[a]anthracene-3,4-diol; anti-7,12-Dimethylbenz[a]anthracene-3,4-dihydrodiol
EINECS	Contact for details

Quality Control

Our 7,12-Dimethylbenz(A)Anthracene-3,4-Dihydrodiol is produced under strict quality protocols to ensure batch-to-batch consistency and high chemical purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and structural confirmation (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under low-light conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.