Description

2-Fluoro-3-Nitro-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its unique combination of fluorine, nitro, and trifluoromethyl substituents. This compound is essential for the synthesis of complex molecules, offering significant advantages in modulating the physicochemical and biological properties of target compounds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance bioavailability and environmental stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and electronic chemicals with tailored properties.
• Cross-Coupling Reactions: The halogen and nitro groups make it a versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Aromatic Substitution: The fluorine atom at the 2-position is highly activated for substitution, allowing for the introduction of various amines, alkoxides, and thiols.
• Library Synthesis for Drug Discovery: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	2-Fluoro-3-Nitro-5-(Trifluoromethyl)Pyridine
CAS No.	72587-16-7
Molecular Formula	C6H2F4N2O2
Molecular Weight	210.09 g/mol
Synonyms	5-(Trifluoromethyl)-2-fluoro-3-nitropyridine; 3-Nitro-2-fluoro-5-(trifluoromethyl)pyridine; 2-Fluoro-3-nitro-5-trifluoromethylpyridine; Pyridine, 2-fluoro-3-nitro-5-(trifluoromethyl)-; 2-Fluoro-3-nitro-5-(trifluoromethyl)pyridine; 72587-16-7
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Nitro-5-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency essential for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.