Description

Phenobarbital-n-Glucoside is a specific glucuronide metabolite of the barbiturate drug phenobarbital. This compound is of significant value in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development, doping control, forensic toxicology, and metabolic pathway elucidation.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of phenobarbital metabolites in biological matrices.
• Metabolite Research: Used in in vitro and in vivo studies to investigate the Phase II conjugation pathways and elimination kinetics of phenobarbital.
• Bioanalytical Method Development: Critical for developing and validating LC-MS/MS, HPLC, or GC-MS methods for therapeutic drug monitoring (TDM) and toxicological screening.
• Forensic & Doping Control: Acts as a key standard in confirmatory testing for phenobarbital use in forensic science and anti-doping laboratories.
• Enzyme Activity Studies: Utilized as a substrate to study the activity and inhibition of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Phenobarbital-n-Glucoside
CAS No.	72209-10-0
Molecular Formula	C17H20N2O9
Molecular Weight	396.35 g/mol
Synonyms	Phenobarbital N-Glucuronide; 5-Ethyl-5-phenylbarbituric acid N-glucuronide; Phenobarbital β-D-Glucuronide; Phenobarbital 1-N-Glucuronide; 5-Ethyl-5-phenyl-1-(β-D-glucopyranuronosyl)-1,3-diazinane-2,4,6-trione; Phenobarbital Glucuronide; PBG; N-Glucuronylphenobarbital
EINECS	Contact for details

Quality Control

Our Phenobarbital-n-Glucoside is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. Keep the container in a dry, well-ventilated place. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.