Description

Bezafibrate Acyl Glucuronide is a key metabolite of the lipid-lowering agent bezafibrate, formed via glucuronidation in the liver. This compound is of critical importance in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism, bioanalytical method development, and regulatory safety assessments.

Application

• Pharmacokinetic and Metabolism Studies: Used as a reference standard to investigate the metabolic pathways, clearance, and half-life of bezafibrate.
• Bioanalytical Method Development: Serves as a critical calibrant and quality control sample in LC-MS/MS and HPLC methods for quantifying bezafibrate and its metabolites in biological matrices.
• Drug-Drug Interaction (DDI) Research: Employed to study potential interactions that may affect the glucuronidation process and overall drug efficacy and safety.
• Toxicology and Safety Assessment: Used in studies to understand the safety profile and potential toxicity of bezafibrate metabolites.
• Regulatory Submission Support: Acts as a characterized impurity or metabolite reference standard for regulatory filings with agencies like the FDA and EMA.
• Stability Testing: Utilized as a benchmark to assess the stability of bezafibrate formulations and monitor degradation products.

Basic Information

Product Name	Bezafibrate Acyl Glucuronide
CAS No.	72156-77-5
Molecular Formula	C26H30ClNO10
Molecular Weight	552.0 g/mol (approx.)
Synonyms	Bezafibrate 1-O-β-Acyl Glucuronide; Bezafibrate Glucuronide; 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid β-1-Glucuronide; Bezafibrate Acyl-β-D-Glucuronide; BZF-Gluc; Bezafibrate Metabolite; Bezafibrate M1; BZF AG
EINECS	Contact for details

Quality Control

Our Bezafibrate Acyl Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This hygroscopic (moisture-sensitive) compound should be handled in a dry environment and allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.