Description

Adenine, [2,8-3H] is a tritium-labeled derivative of the fundamental purine base adenine, a critical building block of nucleic acids. This radiolabeled compound is essential for high-sensitivity tracer studies in biochemical and pharmacological research, enabling precise tracking of metabolic pathways and molecular interactions. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and life sciences sectors for applications requiring exceptional detection limits.

Application

• Biochemical Tracer Studies: Used to investigate the metabolism, incorporation, and turnover of adenine nucleotides in cellular systems.
• Nucleic Acid Research: Employed in the radiolabeling of DNA and RNA probes for hybridization assays and sequencing.
• Drug Discovery & Development: Serves as a key tool in studying the binding affinity, pharmacokinetics, and mechanism of action of novel therapeutic agents targeting purine pathways.
• Enzyme Assays: Acts as a substrate or product in radiometric assays for enzymes such as adenosine deaminase or purine nucleoside phosphorylase.
• Diagnostic Kit Manufacturing: Incorporated into in-vitro diagnostic (IVD) kits and reagents for research use only (RUO).
• Metabolic Pathway Analysis: Tracks purine salvage and de novo synthesis pathways in model organisms and cell cultures.

Basic Information

Product Name	Adenine, [2,8-3H]
CAS No.	72093-28-8
Molecular Formula	C5H33H2N5 *
Molecular Weight	~137.1 g/mol (for unlabeled adenine C5H5N5)
Synonyms	6-Aminopurine, [2,8-3H]; 1H-Purin-6-amine, [2,8-3H]; Tritiated Adenine; [3H]Adenine; Adenine-t; Vitamin B4 (labeled); 9H-Purin-6-amine (labeled); Adenine (tritiated)
EINECS	Contact for details

* Formula indicates tritium ([3H]) labeling at the 2 and 8 positions of the adenine ring.

Quality Control

Every batch of Adenine, [2,8-3H] is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiochemical purity, specific activity, and chemical identity. Certificates of Analysis (COA) detailing lot-specific results for radionuclidic purity, radiochemical purity (by HPLC), specific activity, and chemical purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a dedicated, well-ventilated radioactive materials area at recommended temperatures (typically 2-8°C or as specified on the label). Due to its nature as a highly volatile and light-sensitive material, appropriate shielding and containment must be used in accordance with local radiation safety regulations. Keep away from heat and open flames.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as supplied)
Identification (HPLC/MS)	Conforms to reference standard
Specific Activity	Lot-specific (Ci/mmol or GBq/mmol)
Radiochemical Purity (HPLC)	≥ 95%
Radionuclidic Purity	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied in solution)	Ethanol/Water or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.