Description

3α,17,21-Trihydroxy-5β-Pregnane-11,20-Dione Mono(o-Methyloxime) Bis(Trimethylsilyl) Ether is a high-purity, derivatized steroid intermediate, specifically designed for sensitive analytical and synthetic applications. Its value lies in its role as a protected and stabilized form of a key pregnane derivative, facilitating precise research and development in advanced chemistry. This compound is essential for pharmaceutical R&D laboratories, analytical reference standard producers, and specialized chemical synthesis units working on steroid-based drug discovery and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay development of steroid-based pharmaceuticals.
• Metabolite Analysis: Serves as a derivatized standard in Gas Chromatography-Mass Spectrometry (GC-MS) for the precise identification and quantification of steroid metabolites in biological samples.
• Advanced Organic Synthesis: Acts as a key protected intermediate in the multi-step synthesis of complex steroid molecules and novel therapeutic agents.
• Biochemical Research: Employed in studies investigating steroid hormone pathways, enzyme inhibition, and receptor binding assays.
• Analytical Method Development: Utilized for calibrating instruments and validating analytical methods in compliance with Good Laboratory Practice (GLP).

Basic Information

Product Name	3α,17,21-Trihydroxy-5β-Pregnane-11,20-Dione Mono(o-Methyloxime) Bis(Trimethylsilyl) Ether
CAS No.	72088-35-8
Molecular Formula	C₂₉H₅₁NO₅Si₂
Molecular Weight	549.89 g/mol
Synonyms	5β-Pregnane-3α,17,21-triol-11,20-dione 20-(O-methyloxime) 3,21-bis(trimethylsilyl) ether; 11-Deoxycortisol 20-methyloxime bis-TMS ether; 3α,17,21-Tris(trimethylsiloxy)-5β-pregnane-11,20-dione 20-(O-methyloxime); Reichstein's Substance S 20-methyloxime bis-TMS derivative; 17,21-Dihydroxypregn-4-ene-3,11,20-trione 20-(O-methyloxime) 3,21-bis-TMS ether (related); Cortisol metabolite derivative TMS; Steroid TMS derivative for GC-MS
EINECS	Contact for details

Quality Control

Our 3α,17,21-Trihydroxy-5β-Pregnane-11,20-Dione Mono(o-Methyloxime) Bis(Trimethylsilyl) Ether is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC-MS, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and analytical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (GC or NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.