Description

17,21-Dihydroxypregn-4-Ene-3,11,20-Trione Bis(o-Methyloxime) Mono(Trimethylsilyl) Ether is a high-purity, synthetically modified steroid derivative, primarily utilized as a critical intermediate in advanced pharmaceutical research and development. Its value lies in its specific functionalization, which makes it a key building block for synthesizing complex molecules, particularly in the fields of endocrinology and steroid chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates for drug discovery, process development, and analytical reference standards.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel steroid-based therapeutics and active pharmaceutical ingredients (APIs).
• Research & Development: Used as a reference standard and building block in medicinal chemistry for studying metabolic pathways and hormone activity.
• Analytical Chemistry: Serves as a calibration standard in chromatographic (HPLC, GC-MS) and spectroscopic analyses for method development and quality control.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex organic molecules in pilot plants and manufacturing.
• Biochemical Research: Utilized in studies investigating steroidogenesis, enzyme inhibition, and receptor binding assays.

Basic Information

Item	Details
Product Name	17,21-Dihydroxypregn-4-Ene-3,11,20-Trione Bis(o-Methyloxime) Mono(Trimethylsilyl) Ether
CAS No.	72088-34-7
Molecular Formula	C27H44N2O5Si
Molecular Weight	504.74 g/mol
Synonyms	Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, bis(O-methyloxime), 21-(trimethylsilyl) ether; 17,21-Dihydroxypregn-4-ene-3,11,20-trione bis(O-methyloxime) 21-TMS ether; Cortisone bis(O-methyloxime) 21-TMS ether; 21-Trimethylsilyloxy-17,21-dihydroxypregn-4-ene-3,11,20-trione bis(O-methyloxime); Cortisone TMS methyloxime derivative
EINECS	Contact for details

Quality Control

Every batch of 17,21-Dihydroxypregn-4-Ene-3,11,20-Trione Bis(o-Methyloxime) Mono(Trimethylsilyl) Ether is produced and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.