Description

(4-Amidinophenyl)Methanesulfonyl Fluoride is a specialized chemical building block featuring a unique amidinophenyl group coupled with a methanesulfonyl fluoride (MSF) moiety. This compound matters as a key intermediate in medicinal chemistry, particularly for the synthesis of serine protease inhibitors and other biologically active molecules. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions developing novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of potent serine protease inhibitors targeting conditions like thrombosis and inflammation.
• Biochemical Research: Used as an active site-directed probe or inhibitor in enzymology studies to investigate protease function and mechanism.
• Protease Inhibitor Development: Serves as a core scaffold for creating novel inhibitors for trypsin-like proteases, including thrombin, trypsin, and factor Xa.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) to label and identify active proteomes in complex biological samples.
• Fine Chemical Synthesis: Intermediate for constructing more complex molecules with amidine and sulfonyl fluoride functional groups for diverse applications.

Basic Information

Product Name	(4-Amidinophenyl)Methanesulfonyl Fluoride
CAS No.	71933-13-6
Molecular Formula	C8H9FN2O2S
Molecular Weight	216.23 g/mol
Synonyms	4-Amidinophenyl methanesulfonyl fluoride; 4-(Aminosulfonyl)benzenecarboximidamide; p-Amidinophenylmethanesulfonyl fluoride; APMSF; (4-Carbamimidoylphenyl)methanesulfonyl fluoride; 4-(Methanesulfonylfluoride)benzamidine; Benzamidine, 4'-(fluoromethylsulfonyl)-
EINECS	Contact for details

Quality Control

Our (4-Amidinophenyl)Methanesulfonyl Fluoride is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not typically manufactured to compendial standards (USP/EP), our quality protocols are designed to meet the exacting requirements of pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.