Description

(+/-)-Ppht Hydrochloride (n-0434) Potent D2 Dopamine Re is a high-purity, potent dopamine D2 receptor ligand used in advanced pharmaceutical research and development. This compound is critical for neurological studies, enabling the investigation of receptor binding, signal transduction, and the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) focused on central nervous system (CNS) disorders, neuropharmacology, and drug discovery pipelines.

Application

• Neurological Research: A key tool compound for studying dopamine D2 receptor pharmacology, function, and distribution in the brain.
• Drug Discovery: Serves as a reference standard and pharmacological probe in high-throughput screening (HTS) and lead optimization for CNS-targeted drugs.
• Biochemical Assays: Used in in vitro binding assays (e.g., radioligand binding) and functional assays to characterize receptor interactions and efficacy.
• Academic Research: Facilitates fundamental research into dopamine-related pathways, behaviors, and disorders such as Parkinson's disease and schizophrenia.
• Preclinical Development: Employed in animal model studies to evaluate the pharmacokinetics and pharmacodynamics of potential new therapeutics.

Basic Information

Product Name	(+/-)-Ppht Hydrochloride (n-0434) Potent D2 Dopamine Re
CAS No.	71787-90-1
Molecular Formula	C19H22ClN3O2 • HCl
Molecular Weight	396.31 g/mol (for hydrochloride salt)
Synonyms	(±)-PPHT hydrochloride; N-0434; (RS)-2-Chloro-11-(3-methyl-1,2,4-oxadiazol-5-yl)-6,7,8,9,10,11-hexahydro-7,10-iminocyclohept[b]indole hydrochloride; 2-Chloro-11-(3-methyl-1,2,4-oxadiazol-5-yl)-6,7,8,9,10,11-hexahydro-7,10-iminocyclohept[b]indole hydrochloride; Potent D2 Dopamine Receptor Ligand; Dopamine D2 antagonist N-0434; PPHT HCl
EINECS	Contact for details

Quality Control

Our (+/-)-Ppht Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our commitment to reliable and traceable supply for the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.