Description

Bradykinin, Cyclo (n-(ε-1)-Lys(1)-Gly(6))- is a synthetic, cyclic analog of the endogenous vasoactive peptide bradykinin, designed for enhanced stability and specific receptor interaction. This compound is crucial for advanced research in cardiovascular physiology, inflammation, and pain signaling pathways, offering a valuable tool for studying B1 and B2 receptor mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuropharmacology and drug discovery.

Application

• Pharmacological Research: A key reference standard and tool compound for studying bradykinin receptor (B1 and B2) pharmacology, signal transduction, and desensitization.
• Inflammation & Pain Studies: Used in vitro and in vivo models to investigate the role of the kinin-kallikrein system in inflammatory responses, neurogenic inflammation, and chronic pain conditions.
• Cardiovascular Research: Employed to explore the effects of bradykinin analogs on vascular tone, blood pressure regulation, and endothelial function.
• Drug Discovery & Development: Serves as a lead compound or biochemical tool for screening and developing novel analgesics, anti-inflammatory agents, and cardiovascular drugs.
• Biochemical Assay Development: Used as a calibrated standard in competitive binding assays (e.g., ELISA, RIA) and functional assays to quantify receptor activity and ligand potency.
• Stability & Metabolism Studies: The cyclic structure makes it a model compound for studying peptide stability against enzymatic degradation (kininases) compared to linear bradykinin.

Basic Information

Product Name	Bradykinin, Cyclo (n-(ε-1)-Lys(1)-Gly(6))-
CAS No.	71685-02-4
Molecular Formula	C50H78N14O11
Molecular Weight	1027.2 g/mol
Synonyms	Cyclo(Lys1,Gly6)-bradykinin; c(Lys1,Gly6)-BK; Cyclic Bradykinin analog; Bradykinin cyclic analog; H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH (cyclic 1-6); [Cyclo(Lys1,Gly6)]bradykinin; Lys1,Gly6-cyclo-bradykinin; BK (1-6) cyclic analog
EINECS	Contact for details

Quality Control

Our Bradykinin, Cyclo (n-(ε-1)-Lys(1)-Gly(6))- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot undergoes comprehensive analytical characterization including HPLC, MS, and NMR for identity confirmation and purity assessment. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.