Description

Dametralast CAS NO 71680-63-2 is a specialized pharmaceutical intermediate and active ingredient of significant interest in medicinal chemistry research and development. Its primary value lies in its role as a key building block for synthesizing advanced therapeutic compounds, particularly those targeting inflammatory pathways. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on developing new drug candidates. The consistent high purity and reliable supply of this material are critical for ensuring the reproducibility and success of downstream synthesis and formulation processes.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used extensively in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Anti-inflammatory Drug Development: Functions as a core scaffold or intermediate for compounds being investigated for their anti-inflammatory properties.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Academic & Institutional Research: Utilized in university and government laboratories for pharmacological studies and the development of new therapeutic agents.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Dametralast
CAS No.	71680-63-2
Molecular Formula	C16H16N2O4S
Molecular Weight	332.38 g/mol
Synonyms	Dametralast; 4,5-Dihydro-4-oxo-5-(4-pyridinyl)-2-thiophenecarboxylic acid, 3-(1H-Tetrazol-5-yl)phenyl ester; 3-[3-(1H-Tetrazol-5-yl)phenyl] 5-(4-pyridinyl)-4,5-dihydro-4-oxo-2-thiophenecarboxylate; BAY w 6220; BAY-w-6220; BAYw6220
EINECS	Contact for details

Quality Control

Every batch of Dametralast is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure it meets the high standards required for pharmaceutical development. Our quality control protocols include identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We are committed to supplying material that supports your regulatory filings and ensures process consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.