Description

2-(Difluoromethoxy)Benzaldehyde is a versatile fluorinated aromatic aldehyde building block, offering unique reactivity for advanced chemical synthesis. Its molecular structure, featuring a difluoromethoxy substituent, is critical for modulating the physicochemical properties of target compounds, such as metabolic stability and lipophilicity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorine motifs into novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Organic Electronic Materials: Employed in the research and development of novel organic semiconductors and electro-optical materials.
• Complex Ligand Synthesis: Useful for constructing specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Custom Fluorination Chemistry: A valuable starting material for contract research organizations (CROs) and fine chemical companies specializing in fluorinated compound libraries.

Basic Information

Product Name	2-(Difluoromethoxy)Benzaldehyde
CAS No.	71653-64-0
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	2-(Difluoromethoxy)benzaldehyde; Benzaldehyde, 2-(difluoromethoxy)-; o-(Difluoromethoxy)benzaldehyde; 2-Difluoromethoxybenzaldehyde; 1-(Difluoromethoxy)-2-formylbenzene; (2-Formylphenyl)difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, reducing agents, and strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.